Coronary
health disease (CHD) is a narrowing of the small blood vessels that supply
blood and oxygen to the heart; smoking, high blood pressure, high cholesterol
may also contribute to the development of this disease (Some DOCS, 2012).
health disease (CHD) is a narrowing of the small blood vessels that supply
blood and oxygen to the heart; smoking, high blood pressure, high cholesterol
may also contribute to the development of this disease (Some DOCS, 2012).
People with blood group A, B or AB are risk of
having coronary heart disease compared to O individuals; coronary heart disease
is associated with ABO blood group by supported evidence indicating that
elevated Von Willebrand factor viii (vwf and fviii) levels are a risk factor
for coronary heart disease (Whincup et al,
2002).
having coronary heart disease compared to O individuals; coronary heart disease
is associated with ABO blood group by supported evidence indicating that
elevated Von Willebrand factor viii (vwf and fviii) levels are a risk factor
for coronary heart disease (Whincup et al,
2002).
Von Willebrand Factor
This
is a large glycoprotein produced mainly by vascular endothelia cell and also
contained with platelets; it enhances haemostasis and thrombosis as an
important co-factor in platelet adhesion and aggregation and act as the carry
protein for coagulation factor viii, people with inherited deficiencies of Von
Willebrand factor may suffer a bleeding disorder, Von Willebrand disease, while
substantially increased level are associated with thrombotic disorders (Fosang
and Smith, 2001).
is a large glycoprotein produced mainly by vascular endothelia cell and also
contained with platelets; it enhances haemostasis and thrombosis as an
important co-factor in platelet adhesion and aggregation and act as the carry
protein for coagulation factor viii, people with inherited deficiencies of Von
Willebrand factor may suffer a bleeding disorder, Von Willebrand disease, while
substantially increased level are associated with thrombotic disorders (Fosang
and Smith, 2001).
In detail ABO structure is present in Von Willebrand
factor and it’s about 25% less in blood group O individual’s plasma. It is well
established that low levels of factors viii (fviii) and Von Willebrand of
factor (vwf) are a cause of excess bleeding, increase level make clotting more
likely, increasing the risk of both arterial (Ischemic heart disease) and
venous (thromboembolic disease) problem. Indeed non group O individual have
been shown to be at an increase risk of both coronary heart disease of Von
Willebrand factor
factor and it’s about 25% less in blood group O individual’s plasma. It is well
established that low levels of factors viii (fviii) and Von Willebrand of
factor (vwf) are a cause of excess bleeding, increase level make clotting more
likely, increasing the risk of both arterial (Ischemic heart disease) and
venous (thromboembolic disease) problem. Indeed non group O individual have
been shown to be at an increase risk of both coronary heart disease of Von
Willebrand factor
References
Fosang,
A.J. and Smith, P.J. (2001). To clot or not.
Nature 413:475-6.
A.J. and Smith, P.J. (2001). To clot or not.
Nature 413:475-6.
Some Docs
(2012). Doubt blood types, Heart Disease link, talk of the nation NPR. 20, Aug
17.
(2012). Doubt blood types, Heart Disease link, talk of the nation NPR. 20, Aug
17.
Whincup,
P.H., Danesh, J., Walker, M, et al (2002).
Von Willebrand factor and coronary heart disease: prospective study and mata-analysis.
Eur Heart J. 23: 1764-70.
P.H., Danesh, J., Walker, M, et al (2002).
Von Willebrand factor and coronary heart disease: prospective study and mata-analysis.
Eur Heart J. 23: 1764-70.