Nasopharyngeal
carcinoma (NPC) is a common head and Neck malignant neoplasm. Cigarette
smoking, alcohol consumption, salt preserved food and family history may also
contribute to the development of this disease (Ren, 2010).
carcinoma (NPC) is a common head and Neck malignant neoplasm. Cigarette
smoking, alcohol consumption, salt preserved food and family history may also
contribute to the development of this disease (Ren, 2010).
Previous studies have found out that O type appears
to prevent the growth and spread of tumours (Jaff, 2010).
to prevent the growth and spread of tumours (Jaff, 2010).
The ABO blood group is determined by the expression
of A and B antigen on the surface of red blood cells and anti-A and anti-B
antibodies in the serum. These two antigens are Oligosaccharide antigens
expressed on the membranes of red blood cells and on normal epithelia and
endothelial cells. In most human carcinomas, ABO blood group antigen expression
on cancer cells is modified by hyper-methylation of ABO gene promoter, which is
one of the characteristics of malignant neoplasm (Gao et al., 2004).
of A and B antigen on the surface of red blood cells and anti-A and anti-B
antibodies in the serum. These two antigens are Oligosaccharide antigens
expressed on the membranes of red blood cells and on normal epithelia and
endothelial cells. In most human carcinomas, ABO blood group antigen expression
on cancer cells is modified by hyper-methylation of ABO gene promoter, which is
one of the characteristics of malignant neoplasm (Gao et al., 2004).
The changes in ABO blood antigens on cancer cells
may correlate with tumour invasiveness or metastatic potential, thereby
increasing cells motility through alterations in the glycosylation of
integrins. Furthermore, the core disaccharide structure of the ABO blood group (H)
substance, the thomsenfriedenreich antigen, may influence tumour-endothelial
cell interactions, which are related to cancer metastasis.
may correlate with tumour invasiveness or metastatic potential, thereby
increasing cells motility through alterations in the glycosylation of
integrins. Furthermore, the core disaccharide structure of the ABO blood group (H)
substance, the thomsenfriedenreich antigen, may influence tumour-endothelial
cell interactions, which are related to cancer metastasis.
Individuals with blood type A or AB have increased nasopharyngeal
carcinoma risk than those with blood group O (Turkoz et al., 2011).
carcinoma risk than those with blood group O (Turkoz et al., 2011).
This study is in close agreement with the result
from other cancer, such as pancreatic cancer, hapatocellular carcinoma and
gastric cancer which suggest that the increased risk of cancer is associated
with non-O blood group individuals (Nakao et
al., 2011).
from other cancer, such as pancreatic cancer, hapatocellular carcinoma and
gastric cancer which suggest that the increased risk of cancer is associated
with non-O blood group individuals (Nakao et
al., 2011).
References
Gao, S.,
Worm, J. and Guiderg, P., et al.
(2004). Genetic and epigenetic alteration of the blood group ABO gene in oral
squamous cell carcinoma. Int J Cancer
109: 230-7.
Worm, J. and Guiderg, P., et al.
(2004). Genetic and epigenetic alteration of the blood group ABO gene in oral
squamous cell carcinoma. Int J Cancer
109: 230-7.
Jaff,
M.S. (2010). Higher frequency of secretor phenotype in O blood group, its
benefits in prevention and or treatment of some disease Int J Nanomedicine 5: 901-5.
M.S. (2010). Higher frequency of secretor phenotype in O blood group, its
benefits in prevention and or treatment of some disease Int J Nanomedicine 5: 901-5.
Nakao M,
Matsuo K, Ito H, et al. (2011). ABO
genotype and the risk of gastric cancer, atrophic gastritis and Helicobacter
pylori infection. Cancer Epidemiol Bio
Markers Prev, 20: 1665-72.
Matsuo K, Ito H, et al. (2011). ABO
genotype and the risk of gastric cancer, atrophic gastritis and Helicobacter
pylori infection. Cancer Epidemiol Bio
Markers Prev, 20: 1665-72.
Ren,
Z.F., Liu, W.S., Qin, H.D., et al.
(2010). Effect of Family History of Cancer and Environmental factors on risk of
Nasopharyngeal Carcinoma in Quangdong, China. Cancer Epidemiol 34: 419-24.
Z.F., Liu, W.S., Qin, H.D., et al.
(2010). Effect of Family History of Cancer and Environmental factors on risk of
Nasopharyngeal Carcinoma in Quangdong, China. Cancer Epidemiol 34: 419-24.
Turkoz,
F. P., Celcukoglu, G., Dogu, G.G., et al.
(2011). Risk factors of nasopharyngeal carcinoma in Turkey- an epidemiological
survey of the Anatolian society of medical oncology. Asian Pac J Cancer Prev. 12: 3017-21.
F. P., Celcukoglu, G., Dogu, G.G., et al.
(2011). Risk factors of nasopharyngeal carcinoma in Turkey- an epidemiological
survey of the Anatolian society of medical oncology. Asian Pac J Cancer Prev. 12: 3017-21.
