Mycobacterium Tuberculosis

Mycobacterium
tuberculosis is a pathogenic bacteria species in the family mycobacterium and
the causative agent of most cases of tuberculosis. First discovered in 1882 by
Robert Koch, mycobacterium tuberculosis has an unusual waxy coating on its cell
surface (Primarily my colic acid), which makes the cell impervious to Gram
staining. Acid fast detection techniques are used instead.
The
physiology of mycobacterium tuberculosis is highly aerobic and requires high
level of oxygen, primarily a pathogen of the mammalian respiratory system
mycobacterium tuberculosis infects the lungs. The most frequent used diagnostic
methods for tuberculosis are the tuberculin skin test, acid fast stain and
radiographs.

Mycobacterium
tuberculosis does not retain any bacteriological stain due to high lipid
content in its wall and thus is neither gram- position nor gram- negative hence
zien- neelseen staining or acid fast staining is used. While mycobacterium does
not seem to fit the Gram-positive category from an empirical stand point (i.e.
they do not return the crystal violent stain). They are classified as acid fast
gram-positive bacteria due to their lack of an outer cell membrane.
Mycobacterium
tuberculosis divides every 15 – 20 hours which is extremely slow compared to
other bacteria, which tend to have division that measured, in minutes (Escherichia
coli can divide roughly every 20 minutes). It is a small bacterium that can
withstand weak disinfectants and survive in a dry state for weeks but sensitive
to the heat (Pasteurization) and light. There are species of tuberculosis
bacilli.
1.     
M – Tuberculosis which man is the main reservoir.
2.     
M – Bovis which affect both pig and cattle.
3.     
M – Avium which affect birds.
The
human type produce most of pulmonary lesions, also some extra pulmonary
lesions, other types of tuberculosis bacilli rarely cause disease in human but
infection with these stains may produce immunological changes in the human.
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