This occurs when a mother who is group O with a
high titer of IgG anti-A and anti-B (usually > 1 in 64) in her serum becomes
pregnant with a group A and anti-B cross the placenta and either the foetal
circulation causing destruction of foetal red blood cell of group B infant.
When haemolytic disease of newborn due to ABO incompatibility is suspected and
required investigation, the laboratory should perform ABO cells grouping of the
infant using washed cord cells.
high titer of IgG anti-A and anti-B (usually > 1 in 64) in her serum becomes
pregnant with a group A and anti-B cross the placenta and either the foetal
circulation causing destruction of foetal red blood cell of group B infant.
When haemolytic disease of newborn due to ABO incompatibility is suspected and
required investigation, the laboratory should perform ABO cells grouping of the
infant using washed cord cells.
ABO haemolytic disease of the newborn is rarely
sufficiently severe to require an exchange blood transfusion. In contrast to
rhesus, ABO haemolytic disease of the
newborn may occur in the first pregnancy and may not affect subsequent
pregnancies (Cheesbrough, 2006).
sufficiently severe to require an exchange blood transfusion. In contrast to
rhesus, ABO haemolytic disease of the
newborn may occur in the first pregnancy and may not affect subsequent
pregnancies (Cheesbrough, 2006).
