Changes
occurring in advanced age can have impact on nutritional status, including
modifications in secretion and action of hormones that regulate appetite,
changes in gastrointestinal motility, taste loss and functional decline of
multiple systems, including organs that directly affect drug disposition.
occurring in advanced age can have impact on nutritional status, including
modifications in secretion and action of hormones that regulate appetite,
changes in gastrointestinal motility, taste loss and functional decline of
multiple systems, including organs that directly affect drug disposition.
Several
publications have shown that pharmacokinetics of drugs (including absorption,
distribution, metabolism and elimination) may be modified by nutritional
status, determining therapeutic to toxic response.
publications have shown that pharmacokinetics of drugs (including absorption,
distribution, metabolism and elimination) may be modified by nutritional
status, determining therapeutic to toxic response.
Also drug
distribution might be influenced by nutritional changes occurring in advanced
age. Aging is characterized by changes in body composition, characterized by
gain of fat mass and loss of lean mass. These changes lead to reduction of
drug’s volume of distribution and might result in changes in drug
concentration.
distribution might be influenced by nutritional changes occurring in advanced
age. Aging is characterized by changes in body composition, characterized by
gain of fat mass and loss of lean mass. These changes lead to reduction of
drug’s volume of distribution and might result in changes in drug
concentration.
Metabolism
of many drugs might be impaired by psychological changes observed during aging,
including decreased intestinal blood flow, reduced perfusion of the liver and
kidneys.
of many drugs might be impaired by psychological changes observed during aging,
including decreased intestinal blood flow, reduced perfusion of the liver and
kidneys.
Concerning
drug elimination, renal function progressively decreases with increasing age
and latent insufficiency is a relevant problem in the elderly. The lack of
correlation between lean body weight and muscles mass may determine
over-estimation of creatinine clearance. In addition, dehydration or diuretic
therapy, common concern among older adult, may precipitate acute renal
insufficiency leading to altered excretion of many drug and increased half-life
and risk of late toxicity.
drug elimination, renal function progressively decreases with increasing age
and latent insufficiency is a relevant problem in the elderly. The lack of
correlation between lean body weight and muscles mass may determine
over-estimation of creatinine clearance. In addition, dehydration or diuretic
therapy, common concern among older adult, may precipitate acute renal
insufficiency leading to altered excretion of many drug and increased half-life
and risk of late toxicity.
