The Institute of Physiology and Pathophysiology of
Heidelberg University is inviting applications for a International PhD position
to work on zyxin control of stretch-induced arterial remodeling at Hartmut
Hoffmann-Berling International Graduate School of Molecular and Cellular
Biology (HBIGS). The position will come with a yearly living allowance. The
project includes several weeks of training with collaborators in Amsterdam
(Netherlands) and Münster within the framework of the Marie Curie Initial
Training Network “SmArteR”. Applicant must have spent less than 12 months in
Germany in the last three years (though no restrictions on citizenship) to be
eligible for this position. Send your application online by September 15 2013.
Heidelberg University is inviting applications for a International PhD position
to work on zyxin control of stretch-induced arterial remodeling at Hartmut
Hoffmann-Berling International Graduate School of Molecular and Cellular
Biology (HBIGS). The position will come with a yearly living allowance. The
project includes several weeks of training with collaborators in Amsterdam
(Netherlands) and Münster within the framework of the Marie Curie Initial
Training Network “SmArteR”. Applicant must have spent less than 12 months in
Germany in the last three years (though no restrictions on citizenship) to be
eligible for this position. Send your application online by September 15 2013.
Study Subject(s): This
position is available to work on zyxin control of stretch-induced arterial
remodeling.
Course Level: This position is available for pursuing PhD program at
Hartmut Hoffmann-Berling International Graduate School of Molecular and
Cellular Biology (HBIGS) of Heidelberg University.
Scholarship Provider: The Institute of Physiology and Pathophysiology of
Heidelberg University
Scholarship can be taken at: Germany (The project includes several weeks
of training with collaborators in Amsterdam (Netherlands) and Münster within
the framework of the Marie Curie Initial Training Network “SmArteR”).
position is available to work on zyxin control of stretch-induced arterial
remodeling.
Course Level: This position is available for pursuing PhD program at
Hartmut Hoffmann-Berling International Graduate School of Molecular and
Cellular Biology (HBIGS) of Heidelberg University.
Scholarship Provider: The Institute of Physiology and Pathophysiology of
Heidelberg University
Scholarship can be taken at: Germany (The project includes several weeks
of training with collaborators in Amsterdam (Netherlands) and Münster within
the framework of the Marie Curie Initial Training Network “SmArteR”).
Eligibility:-Must have
spent less than 12 months in Germany in the last three years (though no
restrictions on citizenship) -Master or diploma in biology, biochemistry or
related fields -Knowledge of cell biological, molecular biological as well as
biochemical techniques or willingness to acquire the necessary skills
-Team-minded and flexible -Ability to rapidly familiarize him/herself with new
research areas in theory and Praxis.
spent less than 12 months in Germany in the last three years (though no
restrictions on citizenship) -Master or diploma in biology, biochemistry or
related fields -Knowledge of cell biological, molecular biological as well as
biochemical techniques or willingness to acquire the necessary skills
-Team-minded and flexible -Ability to rapidly familiarize him/herself with new
research areas in theory and Praxis.
Scholarship Open for Students of Following
Countries: International students (must have spent less than
12 months in Germany in the last three years) can apply for this position.
Countries: International students (must have spent less than
12 months in Germany in the last three years) can apply for this position.
Scholarship Description: The Institute of Physiology and Pathophysiology of Heidelberg
University, Division of Cardiovascular Physiology (Prof. Dr. Markus Hecker)
offers a PhD position to work on zyxin control of stretch-induced arterial
remodeling. The focal adhesion molecule zyxin specifically translocates to the
nucleus of vascular cells in response to stretch or hypertension. In the
nucleus, the protein orchestrates expression of a majority of
stretch-/pressure-induced genes, among which mRNAs encoding for matrix proteins
and ECM modifying enzymes are prominent. Aged zyxin-deficient mice show a
reorientation of the arterial smooth muscle cells (SMCs) in response to
hypertension, associated with a more pronounced pressure-induced passive
distension and a failure to up-regulate blood pressure. It appears that adult
zyxin-deficient mice develop a severe deficit in arterial contractility due to
a marked alteration in matrix composition and that the stretch-sensitive
transcription factor zyxin has a major impact on the control of vascular SMC
phenotype. The project will investigate the role of zyxin-controlled ECM
proteins and matrix-modifying enzymes in pressure-induced vascular remodeling
both in vitro and in vivo.
University, Division of Cardiovascular Physiology (Prof. Dr. Markus Hecker)
offers a PhD position to work on zyxin control of stretch-induced arterial
remodeling. The focal adhesion molecule zyxin specifically translocates to the
nucleus of vascular cells in response to stretch or hypertension. In the
nucleus, the protein orchestrates expression of a majority of
stretch-/pressure-induced genes, among which mRNAs encoding for matrix proteins
and ECM modifying enzymes are prominent. Aged zyxin-deficient mice show a
reorientation of the arterial smooth muscle cells (SMCs) in response to
hypertension, associated with a more pronounced pressure-induced passive
distension and a failure to up-regulate blood pressure. It appears that adult
zyxin-deficient mice develop a severe deficit in arterial contractility due to
a marked alteration in matrix composition and that the stretch-sensitive
transcription factor zyxin has a major impact on the control of vascular SMC
phenotype. The project will investigate the role of zyxin-controlled ECM
proteins and matrix-modifying enzymes in pressure-induced vascular remodeling
both in vitro and in vivo.
What does it cover? The position will come with a yearly living allowance in accordance
with the regulations specified by the European Commission for Marie Curie
Initial Training Networks.
with the regulations specified by the European Commission for Marie Curie
Initial Training Networks.
How to Apply: The mode
of applying is online.
of applying is online.
Scholarship Application Deadline: The application deadline is September 15 2013.
