The University of Salzburg invites applications for
two fully funded PhD studentships. The ICA program comprises nine
internationally renowned research groups and focuses on specific immunological
aspects of cancer and allergy.
two fully funded PhD studentships. The ICA program comprises nine
internationally renowned research groups and focuses on specific immunological
aspects of cancer and allergy.
ICA aims to attract and select high-calibre graduate students from all
over the world, provide an intellectually stimulating environment, excellent
infrastructure and ambitious scientific projects. ICA will train
young scientists to the highest international standards preparing them for a
successful career in basic as well as translational and applied science.
Project I
Structure and Mechanism of TPP2 Activation
Structure and Mechanism of TPP2 Activation
The project will focus on structural
characterization (crystallization) of the molecule Tripeptidyl peptidase 2
(TPP2). TPP2 is a cytosolic subtilisin-like serine protease involved in a
number of physiological processes, in particular in the downstream processing
of proteasomal peptides. Its role in MHC class I antigen processing
and its implications in the proliferation of tumor cells attracts increasing
interest.
characterization (crystallization) of the molecule Tripeptidyl peptidase 2
(TPP2). TPP2 is a cytosolic subtilisin-like serine protease involved in a
number of physiological processes, in particular in the downstream processing
of proteasomal peptides. Its role in MHC class I antigen processing
and its implications in the proliferation of tumor cells attracts increasing
interest.
Project II
Peripheral generation of antigen-specific regulatory T cells
Peripheral generation of antigen-specific regulatory T cells
The project will explore T-cell responses to a
tissue-restricted antigen using inducible transgene expression in the skin,
with the aim to study mechanisms involved in the in vivo generation of T-effector
cells and regulatory T-cells. Resulting modulations of the Teff:Treg ratio will
be tested in disease models of autoimmunity and allergy.
tissue-restricted antigen using inducible transgene expression in the skin,
with the aim to study mechanisms involved in the in vivo generation of T-effector
cells and regulatory T-cells. Resulting modulations of the Teff:Treg ratio will
be tested in disease models of autoimmunity and allergy.
ICA offers numerous benefits to its students:
attractive salaries for a period of 3 years (including health, occupational and
national insurance), cover of research consumables, ICA-specific
technological training courses, soft skill courses, full funding of
participation in congresses, workshops and international courses, including
stays in foreign partner laboratories (up to 6 months).
attractive salaries for a period of 3 years (including health, occupational and
national insurance), cover of research consumables, ICA-specific
technological training courses, soft skill courses, full funding of
participation in congresses, workshops and international courses, including
stays in foreign partner laboratories (up to 6 months).
For detailed information about application,
selection procedure and admission, and about the scientific program and faculty
of ICA visit
selection procedure and admission, and about the scientific program and faculty
of ICA visit
