Institute of Cancer Research Higher Scientific Officer Job Vacancy in London and Sutton (Surrey)

Closing Date of vacancy: 2 September 2012

Division: Cancer Therapeutics
Type of Contract: Fixed Term
Length of Contract: 2 years
Salary Range: £30,136 to £33,826 based upon relevant experience
Work Location: London and Sutton (Surrey)
Hours per week: 35

The Institute of Cancer Research (ICR) is one of the world’s most influential cancer research institutes. Our mission is to make the discoveries that defeat cancer. We have a long and distinguished history of research with a major impact on the outcome for cancer patients. Our unique partnership with The Royal Marsden NHS Foundation Trust (RMH) makes us the largest comprehensive cancer centre in Europe, performing high quality original basic research and translational studies. Under the leadership of Chief Executive Professor Alan Ashworth FRS, we are committed to attracting, developing and retaining the best minds in the world.

The Cancer Research UK Cancer Therapeutics Unit, embedded within the Division of Cancer Therapeutics, is a multidisciplinary ‘bench to bedside’ centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. Our exciting goal is to discover high quality drug candidates for validated biological targets and to progress these candidates to clinical trial. All the scientific disciplines are in place to make this possible including medicinal chemistry, biology, drug metabolism and clinical specialists.

A Higher Scientific Officer position is available immediately in our Hit Discovery and Structural Design Team. The successful candidate will support the discovery of novel drugs inhibiting cancer targets involved in chromatin modulation. This work will include cloning, expression and purification of proteins required for biochemical assays. In addition, appropriate molecular biology and mammalian cell culture techniques will be used to generate engineered cell lines for assaying the cellular activity of these targets by high content screening or contemporary methods. The successful candidate will be part of a multidisciplinary project team and interact closely with assay scientists, biologists, structural biologists, computational and medicinal chemists.

Applicants must be educated to degree level in a biological science and will have experience in DNA cloning, protein expression and purification using bacteria, insect and mammalian cell cultures. Experience in epigenetics and chromatin modulation would be an advantage.
Informal enquiries to rob.vanmontfort@icr.ac.uk or rosemary.burke@icr.ac.uk. Please DO NOT send your application directly to Dr van Montfort or Dr Burke, but follow the Apply link below to submit your application.

To apply please Click Here

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