Eawag, the Swiss
Federal Institute of Aquatic Science and Technology, is a Swiss-based and
internationally networked aquatic research institute within the ETH domain
(Swiss Federal Institute of Science and Technology). It is committed to the
ecologically, economically and socially responsible management of water
resources and aquatic ecosystems.
Federal Institute of Aquatic Science and Technology, is a Swiss-based and
internationally networked aquatic research institute within the ETH domain
(Swiss Federal Institute of Science and Technology). It is committed to the
ecologically, economically and socially responsible management of water
resources and aquatic ecosystems.
Within the EU project
EDA-EMERGE the Department of Environmental Toxicology seeks a
PhD in the field of
BIOCHEMICAL ECOTOXICOLOGY
BIOCHEMICAL ECOTOXICOLOGY
EDA-EMERGE aims at
training a new generation of young scientists in the interdisciplinary
techniques required to meet the major challenges in the monitoring, assessment
and management of toxic pollution in European river basins, taking into account
the enormous complexity of contamination, effects and cause-effect
relationships. By integrating innovative mode-of-action based biodiagnostic tools
including in vitro tests, transgenic organisms and “omics” techniques with
powerful fractionation and cutting edge analytical and computational structure
elucidation tools, a new generation of effect directed analysis approaches will
be developed for the identification of toxicants in European surface and
drinking waters.
training a new generation of young scientists in the interdisciplinary
techniques required to meet the major challenges in the monitoring, assessment
and management of toxic pollution in European river basins, taking into account
the enormous complexity of contamination, effects and cause-effect
relationships. By integrating innovative mode-of-action based biodiagnostic tools
including in vitro tests, transgenic organisms and “omics” techniques with
powerful fractionation and cutting edge analytical and computational structure
elucidation tools, a new generation of effect directed analysis approaches will
be developed for the identification of toxicants in European surface and
drinking waters.
Because in vivo
models represent a higher level of organization than in vitro assays, we will
use the zebrafish as model organism and apply proteomic techniques to analyze
and better understand adverse effects of model chemicals and environmental
samples, found to cause effects in in vitro assays, on this organism. In vivo
models cover non-genomic effects and cross-talk between signaling pathways and
all processes needed for homeostasis, growth, reproduction and stress response.
This approach will allow us to identify protein markers that are linked to
specific modes of toxic action. It will also be used to complement results
obtained with DNA microarrays by partners of the EDA-EMERGE consortium and to
compare in vivo and in vitro readouts. The model compounds used will be known
to interact with the hypothalamic-pituitary- adrenal axis (HPA), a major part
of the endocrine system that controls reactions to stress and regulates many
processes, including immune response and reproduction, and as such is a prime
target of xenobiotics.
models represent a higher level of organization than in vitro assays, we will
use the zebrafish as model organism and apply proteomic techniques to analyze
and better understand adverse effects of model chemicals and environmental
samples, found to cause effects in in vitro assays, on this organism. In vivo
models cover non-genomic effects and cross-talk between signaling pathways and
all processes needed for homeostasis, growth, reproduction and stress response.
This approach will allow us to identify protein markers that are linked to
specific modes of toxic action. It will also be used to complement results
obtained with DNA microarrays by partners of the EDA-EMERGE consortium and to
compare in vivo and in vitro readouts. The model compounds used will be known
to interact with the hypothalamic-pituitary- adrenal axis (HPA), a major part
of the endocrine system that controls reactions to stress and regulates many
processes, including immune response and reproduction, and as such is a prime
target of xenobiotics.
If you are excited
about advancing knowledge in linking mode-of-action based biodiagnostic tools,
specifically proteomics techniques, with cutting edge analytical tools and
joining an interdisciplinary research team, you are invited to apply. Your
background should be in biochemistry or analytical chemistry. Excellent
communication skills in English and skills in team work are essential. The
position is available immediately. We offer a stimulating research environment
in a lively and social institute in Dübendorf near Zürich, Switzerland.
about advancing knowledge in linking mode-of-action based biodiagnostic tools,
specifically proteomics techniques, with cutting edge analytical tools and
joining an interdisciplinary research team, you are invited to apply. Your
background should be in biochemistry or analytical chemistry. Excellent
communication skills in English and skills in team work are essential. The
position is available immediately. We offer a stimulating research environment
in a lively and social institute in Dübendorf near Zürich, Switzerland.
Salary will be in
accordance with Marie Curie rules of the European Commission. Besides a full
employment contract, including social security, the candidate will receive
mobility allowances. Note the mobility restrictions outlined by the EC:
Researchers can be of any nationality but at the time of recruitment by the
host organization, researchers must not have resided or carried out their main
activity (work, studies, etc) in the country of their host organization for
more than 12months in the 3 years immediately prior to the reference date.
Applicants must also be in the first four years (date of MSc certificate or
equivalent) of their research careers.
accordance with Marie Curie rules of the European Commission. Besides a full
employment contract, including social security, the candidate will receive
mobility allowances. Note the mobility restrictions outlined by the EC:
Researchers can be of any nationality but at the time of recruitment by the
host organization, researchers must not have resided or carried out their main
activity (work, studies, etc) in the country of their host organization for
more than 12months in the 3 years immediately prior to the reference date.
Applicants must also be in the first four years (date of MSc certificate or
equivalent) of their research careers.
Applications should
include a brief statement describing your motivation to apply, curriculum
vitae, copies of your academic qualifications and the names (with e-mail
addresses) of two potential referees.
include a brief statement describing your motivation to apply, curriculum
vitae, copies of your academic qualifications and the names (with e-mail
addresses) of two potential referees.
Please submit your
application by January 31st 2012. For further information, consult www.eawag.ch or
contact Prof. Kristin Schirmer kristin.schirmer@eawag.ch or Dr. Marc Suter, marc.suter@eawag.ch.
application by January 31st 2012. For further information, consult www.eawag.ch or
contact Prof. Kristin Schirmer kristin.schirmer@eawag.ch or Dr. Marc Suter, marc.suter@eawag.ch.
We
look forward to receive your application.
